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M9470024.TXT
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1994-07-02
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Document 0024
DOCN M9470024
TI [HIV and blood donors: past, present and future]
DT 9409
AU Leon de Gonzalez G; Hernandez T; Arias F; Celis S; Acosta V; Semprun O;
Lugo de Moron M; Banco Municipal de Sangre del D.F. Servicio de;
Inmunohematologia, San Jose Caracas, Venezuela.
SO Sangre (Barc). 1994 Feb;39(1):15-21. Unique Identifier : AIDSLINE
MED/94255827
AB PURPOSE: To evaluate the changes in the spectrum of HIV-positive blood
donors along seven years. PATIENTS AND METHODS: The municipal Blood Bank
of Caracas Federal District examined 193,796 blood donors between 1986
and 1992. Anti-HIV antibodies were determined by the following methods:
Ortho HIV-Elisa Test System (59.5% of the samples), Abbott Recombinant
HIV-EIA (28.6%), Vironostika HIV Microelisa System-Organon Teknika
(2.1%), Bio-Test anti-HIV Recombinant Elisa (2.1%), and Recombigen (env
and gag) HIV Cambridge Biotech (7.7%). Results confirmation was
performed with Biotech/Dupont HIV-I Western Blot Kit, Chiron Riba HIV
216 Test System and Inno-Lia HIV 1/2 Ab immunogenetics SA. RESULTS: Slow
but progressive increase of positive results was seen in the blood
donors along the years, from 0.05% in 1986 to 0.31% in 1992. Higher
prevalence was seen in males (p < 0.001), although absolute increase in
the number of positive females was found by 1992 (p < 0.05). According
to their type, 80.6% of the donors were patient-related (RD), 13%
attended mobile blood-drawing units (MU) and 6.4% were VD (p < 0.001),
with a trend to increase amongst DR and decrease amongst MV. The
majority of the positive donors pertained to homo-or bisexuals (60.5%),
although they showed progressive decrease, whereas the positive findings
increased in the promiscuous heterosexual group and amongst those having
contacts with persons at risk. CONCLUSIONS: High prevalence of
HIV-positive donors is found, the expected figure for 1995 being 0.37%
if the present trends are maintained. Thus, a better selection of blood
donors is recommended by means of careful enquiries, the use of optimal
reagents capable of shortening the window period, deferring people at
risk from blood donation, and promoting altruistic voluntary donation of
blood.
DE Adolescence Adult *Blood Donors English Abstract Female Human HIV
Antibodies/*BLOOD HIV Seropositivity/*EPIDEMIOLOGY HIV
Seroprevalence/*TRENDS *HIV-1 *HIV-2 Male Middle Age Risk Factors
Venezuela/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).